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Not necessarilymild nausea is normal and often decreases after the first few weeks regardless of timing

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In one clinical trial, 5 g of psyllium per day was shown to be superior to docusate sodium as both a stool softener and a laxative (McRorie 1998)

For example, certain GIPR variants are associated with enhanced GIP receptor sensitivity, which could theoretically support stronger response to tirzepatide's dual mechanism in genetically predisposed individuals