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These side effects are usually mild and go away after a few weeks

Sun protection is critical with tretinoin

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Site rotation: Rotate injection sites systematically (abdomen at least 2 inches from navel, outer thighs, upper arms) to reduce local irritation and prevent lipohypertrophy [11]

Interestingly, one clinical report has demonstrated that patients with CRT deficiency exhibit increased GAA levels, as well as the absence of CT in the brain [75], implying a causal relationship between the gene defect of CRT and the increase in brain GAA level

That compounding caution is well-founded