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Omics approaches could then be applied to obtain mechanistic insights into the inferred interactions

However, further experimental, and clinical trials as well as cohort studies have shown that in fact direct mechanisms that could contribute to hepatocyte damage in the course of statin therapy are still not fully known, and the phenomenon of asymptomatic elevation of aminotransferase activity in the course of treatment is rare ( 3 the upper limit of normal (ULN), low-dose statins may be considered, with the need to monitor ALT monthly for 3 months and subsequently 4 per year [8, 9]

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