They showed that administration of their modified long-acting OXM peptide led to a decrease in food intake and increased weight loss in addition to improved metabolic profile, superior to GLP-1 alone over 14 days in diet-induced obese (DIO) mice (69)
FDX1 downregulation activates mitophagy and the PI3K/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production
Preventive and treatment measures:Regular monitoring of blood pressure: During the use of GLP-1 , patients should regularly monitor blood pressure changes, promptly detect blood pressure abnormalities, and take corresponding measures.Adjusting the dosage of antihypertensive drugs: For patients with pre-existing hypertension, it may be necessary to adjust the dosage of antihypertensive drugs in a timely manner under the guidance of a doctor based on blood pressure monitoring results when using GLP-1 drug
The intestinal microbiota colonization produces inflammatory metabolites, which establishes the way for carcinogenesis
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En parallle, ses proprits antioxydantes et anti-inflammatoires permettent de limiter le stress oxydatif et linflammation locale, deux facteurs qui peuvent ralentir la cicatrisation
