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Yet its worth noting that a high positive charge does not necessarily indicate a stronger cell-penetrating ability, that is, the two are not in a simple linear relationship, as researchers have shown that peptides with an NC higher than +7 rapidly reduce cellular pathways [168]

Glucagon-like Peptide 1 Receptor Stimulation as a Means of Neuroprotection

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In essence, GLP-1 RAs might reconfigure the epigenetic characteristics of diabetic cells, offering significant therapeutic benefits in addressing IR and reversing harmful epigenetic alterations linked to aging and metabolic disorders

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Virol., 81, 3170-3180 13