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(PubMed) Jeong HG, Lee YW

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FBXO22 and other ubiquitination machinery are already known to play a vital role in this pathway, and the reactivity of cysteines is frequently altered 13,34,35

With the stimulation of MSU crystals, inflammation onset caused by NETs is mainly induced by the activation of NLRP3 inflammasomes, leading to the release of mature inflammatory cytokines (IL-1 and IL-18)