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A particular challenge for pan-coronavirus vaccines is the diverse use of entry receptors by different coronaviruses (e.g., ACE2 : SARS-CoV-1, SARS-CoV-2, NL63

At high doses (over 3 g), nausea, stomach cramps, diarrhea, and a "fishy body odor" (trimethylamine accumulation) can occur

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