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Concomitantly, water influx causes matrix swelling, rupture of the rigid OMM and release of apoptogenic proteins sequestered in IMS although, apoptotic cell death under MPT is inhibited due to energetic failure and ATP exhaustion and oxidative stress-mediated caspase inactivation

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Generalized Anxiety Disorder (GAD) and Comorbid Major Depression with GAD Are Characterized by Enhanced Nitro-oxidative Stress, Increased Lipid Peroxidation, and Lowered Lipid-Associated Antioxidant Defenses