Data extraction, synthesis, and framework The key details were systematically extracted from each study, including the research design (e.g., randomized controlled trials, retrospective studies, narrative reviews), sample size, participant demographics, treatment protocols (dose, frequency, and duration), outcomes such as weight loss percentage, metabolic improvements, and safety profiles, as well as the statistical significance of findings (e.g., p-values and confidence intervals)
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during which clonidine hydrochloride extended-release tablets was initiated at 0.1 mg/day and titrated up to 0.4 mg/day over a 3-week period
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