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Cotadutide has shown greater promotion of liver glycogen and fat consumption compared to liraglutide

They can stimulate muscle protein synthesis, metabolic activity, and fat oxidation

This technology enables extended pharmacological activity through the site-specific conjugation of a cysteine-albuminconjugated Exendin-4 analog (CA-Exendin-4) to the Fc fragment of human immunoglobulin G subclass 4 (IgG4), linked via a flexible peptide spacer (Fig

At present, there is no oral formulation of retatrutide reported in late-stage clinical trials

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