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Neuropsychopharmacol 41 , 906915 (2016)
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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (marketed as Mounjaro) and chronic weight management (marketed as Zepbound)
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However, subcutaneous delivery bypasses first-pass metabolism in the liver, meaning the niacinamide reaches systemic circulation more directly than oral supplements would
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