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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

Moreover, the traditional rule of asymmetry, border irregularity, color variation, diameter greater than 6 mm, and evolving in a new or changing lesion (the ABCDEs) is not useful in the clinical diagnosis of pigmented lesions of the vulva, in which the history of the lesion is often not known

Skin levels can saturate after repeated application

Their effects on GLP-1 are subtle compared to pharmaceutical options

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Clin Gastroenterol Hepatol 4:387394