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These fibroblasts are central to maintaining the structural framework of the skin, as they secrete collagen and related matrix proteins that provide tensile strength and resilience
The concordance between the proteomic profile and the alterations observed in oxygen consumption, mitochondrial membrane potential, mitochondrial morphology, cellular redox balance, proliferation, migration, and apoptosis provides a coherent framework for unravelling the biological effects of this compound
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This difference became even more pronounced when comparing TCC-treated wounds to control wounds on days 7, 14, and 21, where the TCC group consistently showed significantly smaller unhealed areas
