Here we introduce the existing evidence for GLP-1R expression in different cell types of the joint and a role for the GLP-1/GLP-1R couple in joint homeostasis (see Fig
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Introduction Dipeptidyl peptidase-4 (DPP-4), which is also referred to as adenosine deaminase complexing protein 2 (ADCP2), cluster of differentiation 26 (CD26), or adenosine deaminase binding protein (ADBP), is an important protease that is widely expressed on the surface of human cells
Among single GLP-1 receptor agonists, liraglutide has demonstrated modest efficacy, with an approximate 4.3% reduction in BMI over 56 weeks in adolescents with obesity
A WHO consultation identified the most vulnerable groups as elderly individuals, infants, preschool-aged children, and pregnant or lactating women, due to either increased nutritional demands or impaired absorption capacity ( Addressing the prevention of B12 deficiency and its public health implications requires a comprehensive, life-course approach based on integrated strategies targeting early detection, dietary optimisation, and effective supplementation, in order to mitigate the long-term consequences of inadequate cobalamin status ( Intramuscular (IM) injection is the most invasive and costly administration method, requiring trained personnel and clinical visits
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