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Also, the rare, but serious, side effect of diabetic ketoacidosis can hinder their use particularly in those with longer diabetes duration and limited beta-cell reserves

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Are 'buffalo hump' syndrome, Madelung's disease and multiple symmetrical lipomatosis variants of the same dysmetabolism

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Because of their relative concentrations, a small fractional conversion of ATP to AMP in the RBC yields a large relative increase in AMP concentration, which activates PFK-1