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A randomized clinical trial published in May 2026 in The Lancet investigated whether semaglutide, a GLP-1 peptide that acts as a GLP-1 receptor agonist and is approved for obesity treatment, was associated with changes in alcohol consumption among adults living with both obesity and alcohol use disorder

Overall Implications for T2D Treatment and Safety Monitoring Overall, GLP-1RAs were associated with improved glycemic control and reduced renal, metabolic, and cardiovascular risks, without elevating cancer risk, supporting their use in individuals with cardiorenal comorbidities

In one large clinical trial, participants receiving semaglutide experienced an average weight reduction of approximately 1415% over a 68-week period

Water instead of sugary drinks or alcohol

Semaglutide is a GLP-1 receptor agonist that mimics the bodys natural hormone responsible for regulating appetite, digestion, and glucose control

Around 40-50% of GLP-1 users report nausea or bloating in the early stages of treatment, though symptoms should settle in the first 4-8 weeks as the body adapts (2)