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If it is spreading, burning, swelling, or showing up in new places, stop and reassess

NAC has one of the most robust safety profiles of any supplement in this category and a strong clinical literature base going back decades, including significant research on its role in supporting lung health and liver detoxification pathways

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Anna Pastore, Francesco De Peppo And Anna Alisi have contributed equally to this work Key Points Weight loss is the mainstay of treatment of obesity-related metabolic-associated fatty liver disease (MAFLD)

Old age is a factor causing significant changes in pharmacokinetics, mainly at the stage of distribution (increased content of adipose tissue and 1 acid glycoprotein, reduced water content and albumin concentration) and elimination (impaired renal function, slower hepatic metabolism) [153, 366]

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