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This pattern suggests that MMN enhancement may precede changes to indices of clinical severity, highlighting the possible utility AEPs as a biomarker of treatment efficacy

Previous studies have indicated that the activation of Akt/GSK3 signaling pathway plays a role in UA-mediated neuroprotection in PD and ALS models [136, 171]

Staying on the drugs also did not appear to substantially increase the risks for low or high birth weight or major congenital malformations, although estimates for these outcomes were imprecise

However, they also reported an increased risk of certain medical complications, including myocardial infarction (MI) and acute kidney injuryfindings that contradict earlier literature

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