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For skeletal muscle, IGF-I coordinates with additional growth factors to promote myoblast proliferation, differentiation, and fiber formation during normal growth as well as during regeneration after injury

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It functions as a co-substrate for glutathione peroxidases (GPx) and glutathione S-transferases (GST), and serves as a direct scavenger of reactive oxygen species

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The molecular weight of 159.21 g/mol puts it in the optimal range for cellular uptake studies