More recently, Choi and colleagues evaluated the cost-effectiveness of SGLT2is and GLP-1RAs, taken individually, as first-line therapies for American patients with T2DM, compared with metformin as first-line therapy
Tirzepatide: specific early dosing rules Tirzepatide works differently from semaglutide
This sounds revolutionary, but it has received a mixed reception among clinicians, with many citing concerns that once-monthly dosing may paradoxically worsen patient compliance (patients may simply forget to take the medication, as once-monthly administration may not be frequent enough to build adherence behaviours) and slow dose titration
Besides helping people to control their diabetes and to lose substantial amounts of fat, these compounds appear to offer many additional health benefits
Treatment with GLP-1RA downregulates NF-B activation in hepatic tissue, thereby leading to decreased transcription of cytokines and chemokines that sustain inflammation (23, 24)
Insulin resistance: Review of the underlying molecular mechanisms
