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Enteral Routes (Via Gastrointestinal Tract) Oral (PO) Most common and convenient route Drug absorbed mainly in the small intestine Subject to first-pass metabolism (liver) Clinical Insight: Suitable for chronic therapy but not ideal in vomiting/unconscious patients Sublingual / Buccal Absorption through oral mucosa Bypasses first-pass metabolism Rapid onset Example: Nitroglycerin in angina Rectal Used when oral route is not feasible Partial avoidance of first-pass metabolism Limitation: Erratic absorption 2

This binding triggers a cAMP-mediated signaling cascade that suppresses the transcription of multiple pro-inflammatory genes

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