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These clusters are also labile in the face of environmental insults, such as oxygen toxicity 52
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The healthy synovial tissue is usually free of inflammatory cells, whereas in the diseased state, however, the influx of inflammatory cells and their release of inflammatory factors lead to the diseased of synovial fibroblasts
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Indeed, a 2019 literature review discussed berberines potential for antitumor effects against a few types of cancer, and a more recent review from 2024 highlighted its ability to support chemotherapy.13 49 At this time, the most extensive research on berberine has revolved around its impacts not on cancer but on diabetes and cholesterol management, so those are the health concerns for which the supplement is most likely to yield benefits
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