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When that balance tips, and you lose bone faster than you build it, your bones get more porous and weaker over time. And that can be a problem if you have or are at risk for osteoporosis and are also taking a GLP-1 medication like semaglutide

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BethelMMentzRMerrillPBuseJChanJGoodmanSet alMicrovascular and cardiovascular outcomes according to renal function in patients treated with once-weekly exenatide: Insights from the EXSCEL trial

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Additionally, it helps in enhancing the livers detoxification process and strengthens the immune system

Finally, although it was suggested that insulin resistance might be protective against PBH [26], we did not observe differences in HOMA-IR between the PBH and non-PBH groups