Options include staying at a lower maintenance dose, extending the interval between dose increases, or temporarily reducing the dose
PMID: 19289567 | doi:10.1124/jpet.108.149211 Greenwood-Van Meerveld B et al
Together, these interlinked processes create a pro-fibrotic, pro-mutagenic microenvironment that underlies the transition from chronic liver injury to cirrhosis and HCC
For reference, the daily recommended intake of B12 for adults is just 2.4 micrograms, so 1mg (1,000 micrograms) is roughly 400 times the daily requirement delivered in a single weekly dose
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This concentration is great for studies requiring larger doses, as it keeps the injection volume small