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MALE INFERTILITY Research on male factor infertility demonstrates that sperm are vulnerable to reactive oxidative species (ROS) which can result in decreased motility (due to loss of mitochondria ATP production), decreased viability, increased mid-piece morphology, and reduced fertilization (sperm capacitation and acrosome reaction)

Of note, GSH serves as the terminal product of the GSH synthesis pathway, which utilizes cysteine, glutamate, and glycine as primary substrates