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Semaglutide (Wegovy/Ozempic): The GLP-1 PathwaySemaglutide is classified as a glucagon-like peptide-1 (GLP-1) receptor agonist.2 It works by mimicking the action of a natural hormone called GLP-1, which is released by the gut in response to eating.1 By activating GLP-1 receptors in various parts of the body, semaglutide exerts several effects relevant to weight management and blood sugar control: Enhances Insulin Secretion: It prompts the pancreas to release more insulin, primarily when blood sugar levels are elevated after a meal
62,63 PNs also support fibroblast activity, increasing production of structural and ECM components
doi: 10.1097/01.JAA.0001007388.97793.41
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These effects are typically most pronounced during dose escalation and often diminish with continued use as physiologic adaptation occurs
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