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We demonstrated that Cr GPDH relieves metabolic consequences of the NADH-reductive stress under hypoxia or ETC inhibition at either respiratory complex I or III

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( H ) Influence of SQR depletion on the loss of viability of HeLa cells treated with either RSL3 (5 M) (left panels) or CHP (40 M) (right panels), measured with the CellTox Green cytotoxicity assay