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Unfortunately La Barre's idea was largely forgotten over the next three decades

Here's the quick version: For a 10mg vial: Add 2mL of bacteriostatic water (BAC water) this gives you 5mg/mL For a 0.25mg dose: draw 5 units (0.05mL) on a U-100 insulin syringe For a 0.5mg dose: draw 10 units For a 1mg dose: draw 20 units For a 20mg vial: Add 4mL BAC water same 5mg/mL concentration, same dose math above Injection technique: SubQ injection pinch the skin at belly, thigh, or upper arm 31g or 32g insulin needle ( inch length is fine for subQ) Inject slowly, hold for 5 seconds before withdrawing Refrigerate after reconstitution stable 4-6 weeks in the fridge Realistic Expectations for Weeks 1-12 Here's what most people experience on a conservative titration, assuming reasonable diet and some exercise: Weeks 1-2: Minimal weight change

DiMarchi compares it to solving the 3D combination puzzle invented in 1974 as the Rubik cube

Nearly half of people who say they have been diagnosed with diabetes (45%) report currently using a GLP-1 medication, as do three in ten (29%) adults who say theyve been diagnosed with heart disease and about a quarter (23%) of those who report being diagnosed as overweight or obese in the past five years

In real life, the signal appears strongest in patients who already have retinal disease at baseline, rather than in patients with completely healthy retinas

When you look at your total health in the context of the pros and cons of weight loss, its easy to see a scenario in which trading a small increased risk of thyroid cancer for the potential decreased risk in multiple health conditions AND a reduced risk of overall cancer, is worth it