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In dogs at 52 weeks of treatment at the NOAEL of 40 mg/kg, which is approximately 3 times the MRHD (400 mg) on a mg/m2 body surface area, the AUC7d values were approximately 59 mcgh/mL in males and 44 mcgh/mL in females

For optimal results, MIC B12 injections should be combined with a nutritious, calorie-controlled diet and regular exercise as part of an overall weight management plan