Quantitative weight loss was only reported for the cohort receiving 0.01 mg/kg/24 h via SC infusion for 28 days, indicating an average weight reduction of 3 kg (-3.1%) compared to baseline and nearly 4 kg (-4.06%) compared to placebo as shown by ( Table 2 )
Most of the supplements that market this claim are based on small clinical trials, mostly in mice
The SUPRPASS-4 trial (262), involving 2002 participants with high-risk cardiovascular profiles followed for up to 104 weeks, showed no difference in 4-MACE events (cardiovascular death, myocardial infarction, stroke, and hospitalization for unstable angina) with tirzepatide compared to insulin glargine (HR 0.74
It is also given as a weekly injection, but that dual action may give extra support for some people, especially those with strong insulin resistance or a higher starting body weight
Stockley, Elizabeth Sapey, Charlotte Summers, Andrew S
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