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This energy-intensive process occurs in the mitochondria, where the increased metabolic activity required to produce ATP inherently generates ROS as a byproduct of the ETC (electron transport chain) [84]

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Growth is measured by DNA synthesis and the rate of growth is dependent only upon the functional level of Vitamin B6 available within the cells to support growth

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To prevent DFU, patients with diabetes and DPN should inspect their feet daily for injuries, blisters or signs of infection