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Gastrointestinal Disorders: Certain gastrointestinal conditions, such as pernicious anemia, celiac disease, Crohns disease, and atrophic gastritis, can impair the absorption of vitamin B12 from food, leading to deficiency

Figure 1 outlines the mechanism of regulating hepcidin expression

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Findings in rodents have led to the evaluation of several therapeutic approaches targeted at boosting levels of SOD and/or GPX1 or the use of low molecular weight mimetics to suppress excess ROS in beta cell lines and experimental animals afflicted with various pathologies (Bertera et al