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OpenSource Diets formula D12451) or, if they were previously on an LD, they were maintained continued on LD (termed lean control mice)
Mutant presenilins 1 and 2 disrupt mitochondrial calcium signalling, which leads to decreased ATP production, increased ROS emission, and cell death [78]
Our unique approach addresses not only the hallmark joint hypermobility of EDS but also its systemic complications, including autonomic dysfunction, chronic pain, mast cell issues, and postural instability