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Bacteroides fragilis directly binds to the neurogenic locus notch homolog protein 1 (NOTCH1) receptor on tumor cells via its surface proteins, activating the NOTCH1 signaling pathway and inducing epithelial-mesenchymal transition (EMT) and a stem cell-like phenotype, thereby promoting resistance to 5-fluorouracil and oxaliplatin in colorectal cancer (21)
Before the lag time, 12% of the thyroid cancer group and 9.6% of the control group used GLP-1 receptor agonists, with more than 80% in both groups using liraglutide (Victoza, Novo Nordisk)
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