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Bronchial LN (BLN) cells isolated from the Trx-Tg mice produced an equal amount of Th2 cytokines IL-4, IL-5 and IL-13 as the BLN cells of WT mice after leaving the high Trx environment

Hierarchical virtual screening approaches in small molecule drug discovery

One of the primary obstacles in the treatment of neurodegenerative diseases is the limited transport of large molecules into the brain due to the BBB

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The salt bridge between R283 6.55 and E124 3.33 exists in both antagonist-bound and active ghrelin receptor structure, however, in contrast to antagonist compound 21, ghrelin or GHRP-6 pushes the side-chain of R283 6.55 to swing away from the receptor helical core, which induces rotation of TM6 that initiates the cascade of conformational changes in receptor activation (Fig