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Because of the way patents for small peptides work, anyone can make a small change to a molecule, adding one amino acid here or there and now have a competing product that would not fall under the patent

doi: 10.1007/s00109-017-1592-7 136 BorrmannHMcKeatingJAZhuangX

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It may happen when glutathione is combined with other strong supplements or when the skin reacts differently to internal changes