These compounds are not approved for human therapeutic use by major regulatory agencies, but may be available for research purposes
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On the other hand, the role of both IGFBP2 and IGFBP6 in cancer remains less clearly understood [41]
Similarly, resveratrol has an estimated intestinal absorption of 70% although its plasma bioavailability is less than 1%, due to extensive first-pass metabolism in the liver and intestinal wall, which converts the compound into water-soluble sulphates and glucuronides that are rapidly excreted through bile and urine [54, 55]
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