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doi: 10.1111/dom.14067 177 LiRSheDYeZFangPZongGZhaoYet al

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However, clinical data emphasizes the importance of combining weight loss medication with sustainable lifestyle changes such as regular exercise and optimized nutrition to maintain the weight loss achieved

Clinical Safety Data: What the Research Shows Large randomized controlled trials, including the STEP trials (Semaglutide Treatment Effect in People with obesity), enrolled over 4,500 participants and demonstrated that semaglutide maintains a favorable safety profile when dosed appropriately

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The GLP-1 receptor agonists cardiovascular benefits are believed to stem from their effects in reducing dysfunctional body fat cells, improving glycemic control, reducing blood pressure and inflammation, and perhaps improving vascular endothelial function and plaque stability