Given the progressive nature of the disorder, disease pathogenesis is mainly triggered by continual processes such as geometric accumulation of oxidative radicals brought about by cellular inclusions and mitochondrial dysfunction 8,9,10
10.1016/j.jsbmb.2007.09.011 J
Dringen, R., Brandmann, M., Hohnholt, M
This oxidative burst serves dual roles: while moderate ROS levels activate antiviral signaling, excessive ROS production triggers mitochondrial permeability transition, mtDNA release, and cell death (Kayesh et al., 2025)
Research has found plasma glycine, serine and glutamate concentrations to be consistently altered in metabolic diseases, as are plasma branch chain amino acids (BCAA), isoleucine, leucine, and valine
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