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Inability to collect sample for primary outcome: As a supplementary analysis for the primary estimand, the missingness at random assumption will be evaluated for any patient or system related intercurrent events preventing the collection of the primary outcome

doi: 10.1001/jamaneurol.2020.1840

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In particular cases, such as traumatic brain injuries, certain brain tumors, or seizures triggered by environmental or other clinical factors, patients may be placed on prophylactic medications

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