I ran a biochemical optimization program a while back, and one of the clients that I had in there, he tried methylene blue, and he only got up to a half a milligram or a milligram, and his mood was worse, his fatigue was worse, he had more anxiety, a bunch of problems that, you know, the dose was too low to say it was doing a pharmacological messing with his neurotransmitters
ElSayed NA, Aleppo G, Aroda VR et al (2023) 8
When combined with protein, it increased muscle protein synthesis rates significantly beyond protein alone in resistance-trained individuals
and reduce likelihood of longterm weight maintenance (especially if GLP1 therapy is stopped)
It slows gastric emptying and increases feelings of fullness, reducing overall caloric intake
Selfotel in acute ischemic stroke : possible neurotoxic effects of an NMDA antagonist