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Peptide therapy requires medical supervision and is contraindicated in patients with active malignancy, uncontrolled diabetes, or diabetic retinopathy

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Real-world use of oral semaglutide in adults with type 2 diabetes in the PIONEER REAL Netherlands multicentre, prospective, observational study

The results are mixed: some musculoskeletal studies show enhanced local healing with proximal injection, while others show comparable efficacy between subcutaneous and peri-lesional routes

Metformin, an inexpensive and widely-used medication for type 2 diabetes, is one such alternative