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It has been shown to upregulate choline acetyltransferase (ChAT) activity, increasing the biosynthesis of acetylcholine, the primary neurotransmitter of the parasympathetic ("rest-and-digest") nervous system

The odds ratios for weight loss of 10%, 15%, and 20% or more ranged from 14.5 to 27.3, indicating a substantially higher likelihood of achieving these goals than placebo

Guided by diagnostic lab testing and ongoing monitoring, TRT may help support improvements in energy, physical performance, mood regulation, libido, and metabolic health when medically appropriate

The second mechanism is central

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