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These discoveries gain additional significance in light of recent evidence linking ferroptosis induction to enhanced immunotherapy efficacy, where GSH depletion-triggered ferroptosis can boost anti-tumor immunity through promoting the maturation of dendritic cells and the priming of CD8 + T cells [36]

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Notably, adipocytes from Gcgr / mice failed to induce lipolysis upon G49 treatment, suggesting a lipolytic action, at least in part, via GCGR as it will be discussed below

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