Social isolation impairs the persistence of social recognition memory by disturbing the glutamatergic tonus and the olfactory bulb-dorsal hippocampus coupling
As the medication works by mimicking the GLP-1 hormone, it helps regulate hunger signals in the brain, leading to reduced cravings and increased satiety
It works primarily by increasing the activity of telomerase, an enzyme responsible for maintaining and lengthening telomeres the protective caps at the ends of chromosomes that determine cellular lifespan
Mutations in SLC26A1 cause nephrolithiasis
Participants receiving the highest dose (12 mg weekly) achieved a mean body weight reduction of approximately 24% from baseline at 48 weeks a figure that, whilst encouraging, should be interpreted with caution as cross-trial comparisons with approved agents are not methodologically robust in the absence of head-to-head data
Two possible mechanisms of NO-mediated protein S-glutathionylation can be envisioned: through a GSNO (activated thiol) formation and its consequent reaction with protein-thiol (179) or through an intermediate protein-thiol nitrosylation (activated protein-thiol: analog of sulfenic acid) and its consequent reaction with GSH
