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National Registration Number:113031/2511-2025

Bagsvaerd, Denmark: Novo Nordisk A/S

Based on animal reproduction studies showing fetal harm at clinically relevant exposures, the FDA recommends that semaglutide should be discontinued at least 2 months before a planned pregnancy due to its long washout period (approximately 5 weeks after the last dose)

Plutzky J, Garber A, Falahati A, Toft AD, Poulter NR

In patients with syndromes like Laugier-Hunziker and Peutz-Jeghers mucosal melanosis can be diagnosed in high frequencies and in patients with inflammatory skin diseases like lichen planus genital melanosis have been reported (5,7-9)

Some are rapidly broken down by enzymes in the body, while others are engineered for extended stability and slower clearance