20 NRF2 was first identified in 1994, 21 and by 1996, 22 it had been discovered that under oxidative stress conditions, it could activate the expression of antioxidative enzyme genes, including NQO1, GPX4, TXN, and PRDX1
BBB plays a crucial role in the maintenance of CNS homeostasis (Erickson and Banks, 2013)
SLC7A11 protects cells from ferroptosis caused by cystine starvation (Stockwell and Jiang, 2020)
GHK-Cu works by forming a complex with copper ions, which are involved in many important biological pathways
For BSO treatment, cells were GSH starved for 48 h before washing and addition of EV-F3 and further 0.4 mM BSO (Sigma)
Lancet 393 , 17451759 (2019)