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Orphanet J Rare Dis 16 , 215 (2021)

(in press)

VDAC, a protein related to the NLRP3 inflammasome 74 , is known to regulate mitochondrial ROS production 97

It will provide an overview of the brains biology in relation to alcohol addiction, and then delve into detailed reviews of recent papers on the genetics of alcohol addiction

Weight loss appears to improve mitochondrial function, which helps improve muscle health through more efficient use of fuel sources

Notably, serum-based fibrosis scores (e.g., ELF test incorporating HA, PIIINP, TIMP-1) have already gained FDA breakthrough designation and are integrated into ongoing phase II/III clinical trials for MASLD drug development [341]