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In the STEP 1 clinical trial, adults using semaglutide 2.4 mg alongside lifestyle changes lost an average of about 15% of their body weight over 68 weeks individual results vary, and weight typically returns if the medication is stopped without other changes

2020;64:S38

It is recommended that you follow a restricted-calorie diet and increase your exercise output while taking semaglutide to achieve the full benefits of the medication

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In contrast, one study showed that exendin-4 did not attenuate remifentanil self-administration or opioid withdrawal symptoms in mice

In theory, this means it could reduce pigmentation