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IGF-2 is involved in regulating cell proliferation and apoptosis, both of which can influence tumor development and progression

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However, it increased heart rate, cardiac output, and induced myocardial degeneration in mice and thus was terminated as a preclinical candidate (Yau et al., 2017)

It enhances hepatocyte proliferation, migration, invasion, cytoskeletal remodeling, and lipid dysregulation, further promoting liver injury and carcinogenesis (4548)

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Obesity leads to a constant state of low-grade inflammation, which not only makes arthritis pain and swelling worse but also raises your risk for diabetes, heart attacks, and even early death